Once a respected and brilliant scientist, Dr. Victor Fries turned to a life of crime after his wife, Nora Fries, whom Victor cryogenically froze to develop enough time to create a cure for her rare illness, was stolen away from him by his CEO, Ferris Boyle. In the confusion, Fries was drenched in the cryogenic chemicals that he had created to freeze Nora, which changed his metabolism. The result was Mr. Freeze, a cold blooded villain motivated by the desire to save and cure his wife and kill anyone who would stand in his way. Though Nora was saved by Batman, Freeze regards the hero as an adversary for stopping his revenge against Boyle and continues in his plans and attempts to cure his wife through crime.
Within the confines of Arkham City, Freeze is blackmailed to perform the will of both The Joker and Hugo Strange under the threat of his wife's death. While using his medical expertise to reluctantly aid these villains, Freeze's cold, dark rage would only be amplified as he made his own plans for revenge and ensure Nora's safety.